Tag Archive for: Grants


Part I: What are SBIRs/STTRs?


The total pocket of non-dilutive funding from the US government is around $50B annually. Most of the non-dilutive funding for life sciences, biotech and medtech comes from the National Institutes of Health (NIH) – around $28B in 2018 (against a total budget of $37B). Through the 24 funding institutes at the NIH, numerous indications can be funded. So, no matter your field, the NIH can potentially fund your project.

One mechanism for non-dilutive funding from the NIH is SBIR (small business innovation research)/STTR (small business technology transfer). These are congressionally-mandated programs – money must be set aside each year – whose goal is to strengthen the role of innovative small businesses in federally funded R&D: “support scientific excellence and technological innovation through the investment of federal research funds in critical American priorities to build a strong national economy.”

Any institute with an extramural R&D budget over $100M must allocate 3.2% of that budget for SBIR and institutes with an extramural R&D budget over $1B must allocate for 0.45% for STTR each year. SBIR is available for domestic (US-based) small business concerns (SBCs). While the goal is to help small business engage in R&D – the NIH specifically looks for those with potential for commercialization.

Look for An Intro to SBIR/STTR Part II next week!


  • Know Your Audience

Know your audience – the institute from which you are applying for a grant. Your project should address their areas of interest. To identify these areas, check the institute’s website, review the study section description, and look at the rosters of previous meetings as well as previous awards made.

  • Create Bite-Sized Pieces

Plan your research strategically by creating bite-size pieces. Define a singular, focused goal that encompasses the research aims under a single concept. The research can also be divided into several distinct proposals, submitted either simultaneously or one-by-one.

  • Find the Middle Ground

Innovation is a double-edged sword – pioneering work can significantly advance a research field, but involves a lot of risk. Review groups tend to be conservative, and so to win, you need to find the middle ground. Your research should be novel but also grounded with supporting literature.

  • Establish a Reputation

Your name should be synonymous with the research at hand. Publish your work, attend conferences, establish networks with others in the field and working relationships with relevant laboratories and institutions.

  • Assemble Experts

Reviewers need to know that you can undertake the proposed tasks, even if unforeseen snags arise. Choose collaborators to complement your capabilities; if necessary, recruit a consultant, collaborate with a laboratory, or subcontract a CRO. The governmental grantor itself may be available for collaboration or contribution of human or laboratory resources.

  • Dedicate the Time

Writing a grant proposal is a complex process that requires a significant time commitment. Set aside several weeks or months for the process; depending on the size of the project and level of preparedness. It will require several drafts, and the more you review the drafts, the more you can edit, and the better your final proposal will be.

  • Ask for Help

It is always best to turn to others to review your application and offer unbiased input. These can be colleagues, supervisors, current or former employees. Consultancy firms, such as the FreeMind Group, with years of experience writing grants, familiarity with funding agencies, and the benefit of an unbiased view, are a valuable source of guidance.

  • Get Their Attention – and Keep It!

Your proposal will likely be read at 10 PM, after a full day’s work and along with seven other 80-page proposals. Of a 20-30-member panel only 3-4 will read your application in full, while others skim it for important points. Write the proposal in a reader-friendly manner: break the text into sections with informative titles; stress important points; keep paragraphs short; and change sentence structure. Pictures, figures, graphs, and flowcharts are also helpful.

  • Details, details, details

A grant proposal should paint the most complete picture possible of the research. The reviewers must understand exactly what you want to do and how you intend to do it. You need to guide them through the preliminary data, hypothesis, research design, methods, interpretation, and future directions. Any gap will have the reviewers doubting your ability to complete that step.

  • Have No Fear

Don’t fear rejection; it’s in your best interest to submit as many high-quality applications as your research will support. It’s not easy money, but it is an excellent source of funding. If at first you don’t succeed, try, try again.

Adam Ruben

doi:10.1126/science.caredit.a1600164

‘Twas the night before grant deadline, 7:15.
Many creatures were stirring, thanks to caffeine.
The comments accepted, the references done,
In hopes someone might fund my first R01.

I wrote like a showman. My prose was terrific.
My font was New Roman. My aims were specific.
I showed prior data and new innovation—
I even nailed my budget justification.

The footnotes were hung like superscript pendants,
Each at the end of a well-crafted sentence.
I sighed with relief; it had all turned out fine,
And I dreamed of the day when I’d hear the pay line.

I’d labored for months while my spouse gazed with pity:
This would have to influence my tenure committee.
The time and the effort I’d spent really showed.
Now the grant was complete; it was time to upload.

When what should my wondering eyes chance to scan
But the tiniest typo in my research plan?
Then more and more errors came as I read through!
And I knew it would never survive peer review.

So quickly I rose from my chair made of vinyl
And opened the files I’d all labeled “FINAL.”
“Sweet merciful Darwin!” I cried to the heavens.
“There’s no Figure 6! There are two Figure 7s!”

My spacing was shrunk and my margins too wide!
My titles and headings were right-justified!
Even the sections I’d thought in grand shape
Had been converted from portrait to landscape!

What fate had befallen my grant so idyllic?
The tables were merged—and is that Cyrillic?
So many errors! Oh, how could this be?
All I did was convert from Mac to …

Uh-oh.

Now swiftly I read one line to the next,
Putting symbols back in and repairing the text,
Fixing all of the words over which I had sweated,
The objects and worksheets that now were embedded.

“But it’s science!” I screamed, my heart pitter-patting.
“Why must I spend all my time on formatting?
Why would anyone panic? Why would they care if
My spacing was close, or my font had a serif?”

When all of a sudden, there came such a din
That I ran to the door—and then he walked in.
“Cease your worry!” said he, in his bold way of talking.
“All good scientists get a grant in their stocking.

You’ve done all the research that one could deem prudent.
(Well, not you—your postdocs and graduate student.)
Your grant is the greatest thing since streptomycin!”
And I knew right away he was Neil deGrasse Tyson.

He was dressed in a blazer; his elbows were patched.
And, like most astronomers, none of it matched.
His mustache, so bushy! His loafers, how dirty!
His visage, so kind, and his necktie, how nerdy!

“Oh please, Dr. Tyson!” I then interrupted.
“The grant is due soon, and my file’s corrupted!
If my department chair sees that I’ve flunked,
I might be demoted to teaching adjunct!”

With a wink and a nod and a friendly high-five,
He placed in my hand a USB drive.
The files it held were my own grant, but better!
He even provided a new cover letter!

As I marveled and gawked at my mended submission,
With every page break in its proper position,
He climbed in his sleigh. (Why a sleigh? Don’t ask me.)
He took up the reins, and he shouted with glee:

“Now funding! Now finance! Now tech transfer offers!
On private foundations! On government coffers!
Now sit back and watch as your budget increases
For keeping your postdocs on H1-B visas!”

“Oh, thank you!” I yelled, “for each PDF’d page!
My lab techs will cheer at their new living wage!
On supplies and equipment we’ll run up a tab.
My undergrads won’t have to sleep in the lab!”

I dreamed of results from the money we’d spend,
Professional meetings we now could attend,
The safety routines we’d bring up to compliance,
The last-author papers I’d publish in Science.

For grant applications are vaguely abusive;
Funding is fleeting and tenure elusive.
In science, we struggle for basic support.
I guess we’re less vital than, say, a sport.

He pointed his sleigh toward a twinkling star,
Then flew off to help with an SBIR.
And I heard him exclaim, in a voice to enchant,
“Merry deadline to all! Now go start your next grant.”

 

Read online

In order to maximize your funding potential, all sources of funding must be considered, including the less traditional ones.

The NIH’s R21 mechanism aims to fund very early stage proof of concept type programs of up to 2 years at about $300,000, whereas the R01 mechanism is more suitable for longer programs of up to 5 years, totaling close to $3,000,000. Other agencies such as the Department of Defense, BARDA, FDA, and NSF also have awards for research in the life sciences.

In this webinar, we share insight into alternatives to the classic SBIR/STTR mechanisms. We will discuss methodology for establishing both responsiveness as well as competitiveness and how to increase chances for award.

View Slide Deck

SBIR/STTR awards account for over $780,000,000 awarded per year by NIH alone. These are excellent sources of funding aimed at promoting R&D activities of US-based small businesses as well as collaborations with Academics.

SBIR/STTRs differ from traditional NIH mechanisms in that they are highly product driven and ultimately are seeking commercialization of novel therapies, diagnostics, devices, etc.

In this webinar, we discuss process for applying, guidelines, key success components and insight into increasing chances for award.

View Slide Deck